Predicted Species Reactivity:MouseProduct Format:Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.Clonality:PolyclonalHost:RabbitApplication:WBReconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.Gene Symbol:UBE2NOfficial Gene Full Name:ubiquitin-conjugating enzyme E2NNCBI Gene Id:93765Protein Name:ubiquitin-conjugating enzyme E2 NSwissprot Id:P61089Protein Accession #:NP_542127.1Nucleotide Accession #:NM_080560.3Alias Symbols:UBC13, AL022654, BB101821, 1500026J17RikDescription of Target:The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:22424771, PubMed:28039360). This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.Protein Size (# AA):152Molecular Weight:16 kDaPurification:Affinity purifiedTissue Tool:Find tissues and cell lines supported by DNA array analysis to express UBE2N. 
RNA Seq:Find tissues and cell lines supported by RNA-seq analysis to express UBE2N. 
Immunogen:The immunogen is a synthetic peptide directed towards the middle region of mouse UBE2NPeptide Sequence:Synthetic peptide located within the following region: IRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNConcentration:Batch dependent within range: 100 ul at 0.5 - 1 mg/mlBlocking Peptide:For anti-UBE2N (ARP90265_P050) antibody is Catalog # AAP90265Datasheets/Manuals:Printable datasheet for anti-UBE2N (ARP90265_P050) antibody Aviva为每个蛋白质表达项目提供定制的解决方案。我们专业的科研人员对困难的蛋白质具有丰富的经验，并已生产出2500多种重组蛋白质。无论您的需求是小型研究还是大型cGMP，我们都可以运用我们的经验来满足您的需求。服务包括大肠杆菌表达，哺乳动物表达，酵母表达和抗原制备。
