Description

PEG (Acetic Acid)2 (PEG di-acetic acid or PEG dicarboxyl) with superior quality specification of ≥95% Substitution.

PEG (Acetic Acid)2 from JenKem Technology is a homobifunctional PEG employed for amine pegylation and crosslinking, reactive towards the amine group of lysine(s). Homobifunctional PEG derivatives from JenKem Technology have numerous applications as crosslinkers for PEGylation of proteins and peptides, nanoparticle and surface modifications. Conjugation with homobifunctional PEGs ensures an increased drug load compared to pegylation with linear PEGs. JenKem Technology offers Acetic Acid PEG Acetic Acid with MW 2,000 Da (CM-PEG2000-CM), MW 3,500 Da (CM-PEG3500-CM), MW 5,000 Da (CM-PEG5000-CM), and MW 7,500 Da (CM-PEG7500-CM), in 1g and 5g packing sizes.

Different MW of PEG (Acetic Acid)2 may be available by custom synthesis, please email us at tech@jenkemusa.com for details on custom PEGs. JenKem Technology provides repackaging services for an additional fee, please contact us if you require a different package size than our catalog selection.

Bulk PEGs and GMP grade PEGs are made-to-order. Please contact us for bulk pricing.

Note: Starting July 2016, PEG (Acetic Acid)2 is the new name of the product Carboxyl PEG Carboxyl (MW 2000 Da (COOH-PEG2000-COOH), MW 3500 Da (COOH-PEG3500-COOH), MW 5,000 Da (COOH-PEG5000-COOH), and MW 7500 Da (COOH-PEG7500-COOH); or PEG Dicarboxyl. JenKem Technology has revised the name of the product to better reflect the chemical structure, as many other PEG derivatives with COOH group are offered in the catalog.

References:

1. Wang, C., et al., Synthesis and formation mechanism of bone mineral, whitlockite nanocrystals in tri-solvent system, Journal of Colloid and Interface Science, 2020, V. 569, P. 1-11.
2. Ji, F., et al., A Dual pH/Magnetic Responsive Nanocarrier Based on PEGylated Fe3O4 Nanoparticles for Doxorubicin Delivery, Journal of Nanoscience and Nanotechnology, 2018, 18.7: 4464-4470.
3. Xiao, S., et al., Aptamer-mediated gene therapy enhanced antitumor activity against human hepatocellular carcinoma in vitro and in vivo, Journal of Controlled Release, 2017.
4. Jing, P., et al, Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system, Cancer Letters, 2016, V. 383(2), P. 230-242.
5. Lorenzo, M. M., et al., Homodimeric Protein–Polymer Conjugates via the Tetrazine–trans-Cyclooctene Ligation, Macromolecules, 2015.
6. Xue, Y., et al., Quantifying thiol–gold interactions towards the efficient strength control, Nature communications, 2014, 5.
7. Xu, P., et al., Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials, 2014, 35(26): p. 7574-7587.
8. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nanoscale, 2014, 6(1): p. 521-31.
9. Gao, X., et al., Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy. Int J Nanomedicine, 2012, 7: p. 4037-51.

Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes exclusively in the development and manufacturing of high quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services. JenKem Technology is ISO 9001 and ISO 13485 certified, and adheres to ICH Q7A guidelines for GMP manufacture. The production of JenKem® PEGs is back-integrated to in-house polymerization from ethylene oxide, enabling facile traceability for regulated customers. JenKem Technology caters to the PEGylation needs of the pharmaceutical, biotechnology, medical device and diagnostics, and emerging chemical specialty markets, from laboratory scale through large commercial scale.

enKem Technology利用数十年来在创新PEG和单分散PEG衍生物，PEG共聚物和PEG化共轭物的研究，开发和制造方面的专业知识，提供定制PEG合成服务。JenKem Technology已为许多PEG相关技术申请了专利，并尊重他人的知识产权。2020年7月，JenKem Technology获得67项专利批准（中国35项，美国20项，欧洲8项，日本3项，澳大利亚1项），48项待批专利申请（中国22项，美国16项，欧洲5项，1项）印度，巴西1，韩国1、2 PCT），向FDA提交的几种DMF以及正在开发的许多其他创新技术。我们将聘请我们经验丰富的专业技术支持专家来帮助您为您的项目确定正确的高质量PEG。JenKem Technology的研发团队将开发和合成您的PEG或PEG共聚物产品，以在最短的时间内以最高的质量满足您项目的独特需求。通过专用的PEG化服务提供  定制的PEG化缀合物。JenKem Technology还通过定制合成来制造GMP级PEG衍生物和批量订单，从而提供了满足客户特殊质量要求的机会。根据ICH Q7A准则，JenKem Technology能够根据ISO 9001和ISO 13485认证的质量管理体系开发和合成多种GMP PEG衍生物。JenKem Technology可以帮助客户向美国FDA提交DMF，并具有在全球范围内申请专利以保护客户利益的能力。有关JenKem Technology的定制PEG合成服务的详细信息，请通过tech@jenkemusa.com与我们联系。有关我们当前的PEG产品目录的信息，请访问  左侧的PEG产品页面。对于可能有现货的定制产品，请定期访问此链接。JenKem Technology由PEG合成和PEG化的专家成立于2001年，专门研究和生产高质量聚乙二醇（PEG）产品和衍生物，以及相关的定制合成和PEG化服务。JenKem Technology已通过ISO 9001和ISO 13485认证，并遵守ICH Q7A GMP制造准则。JenKem®PEG的生产已从环氧乙烷反向整合到内部聚合中，从而为受监管的客户提供了简便的可追溯性。从实验室规模到大型商业规模，JenKem Technology均可满足制药，生物技术，医疗设备和诊断程序以及新兴化学专业市场的聚乙二醇化需求。