About InVivoMAb anti-mouse ICOS
The 7E.17G9 monoclonal antibody reacts with mouse ICOS (inducible T cell co-stimulator). ICOS is a 47-57 kDa homodimeric glycoprotein belonging to the CD28 family of costimulatory molecules. ICOS is expressed on activated T cells and upon ICOSL binding, co-stimulates T and B cell responses. The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. ICOS signaling is also thought to be important for maintaining regulatory T cell homeostasis. The 7E.17G9 antibody has been shown to block the binding of ICOSL to ICOS in vivo.
InVivoMAb anti-mouse ICOS Specifications
| Isotype | Rat IgG2b, κ |
| Recommended Isotype Control(s) | InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin(BE0090) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 8.0 Dilution Buffer(IP0080) |
| Immunogen | Mouse ICOS cDNA and ICOS hexahistidine fusion protein |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_1107622 |
| Molecular Weight | 150 kDa |
