Sepharose^® 6B affinity chromatography beads covalently modified with steroids or other ligands such that ligand binding to receptors is not compromised resulting in high receptor-binding specificity.

• Efficient isolation and purification of receptor proteins (nuclear and others)
• Ligand binding affinity studies
• Preparation of receptor-ligand complexes for crystallography studies.
• Assisting in the structure-based design of receptor selective ligands (e.g. see Manas et al.)

Typical ligand loading: 10-14μmoles/mL bead.

^{Sold under license from PTI Research, Inc. to MTTI and distributed by Polysciences, Inc. Sepharose is a trademark of GE Healthcare.}

转染技术新宠-Polysciences阳离子聚合物基因转染技术 其优点：适用宿主广泛，操作简便，细胞毒性小，转染率高。其中聚乙烯亚胺（PEI）的转染性能最好。聚乙烯亚胺是一种具有较高的阳离子电荷密度的有机大分子，每相隔两个碳原子，就是第三个原子都是质子化的氨基氮原子，使得聚合物网络在任何PH下都能充当有效的“质子海绵”体。这种聚阳离子能将各种报告基因转入各种种属细胞，其效果好于脂质聚酰胺，而且细胞毒性低。大量实验证明，PEI是非常有希望的基因治疗载体。目前在设计更复杂的基因载体时，PEI经常做为核心组成成分。