CAL-101 (idelalisib or GS-1101) is a potent inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with IC50 of 2.5 nM in cell-free assays. CAL-101 decreases pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM.

Additional Information

Product Name: Also Known As: Catalog No.: Size: CAS: Formula: Molecular Weight: Form: Quality Assurance: Source: Storage: PDF Data Sheet: Image(s): Shipping Method: References:

CAL-101 (Idelalisib, GS-1101)

(S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

F6181

25 mg

870281-82-6

C22H18FN7O

415.42 Da

Lyophilized powder

>98% by HPLC and NMR

Synthetic

Eligible for room temperature shipping. Store at -80°C upon receiving

Download PDF datasheet

N/A

Room temperature shipping

Lannutti BJ, et al. (2011) Blood, 117(2), 591-594.

Details

CAL-101 (idelalisib or GS-1101) is a potent inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with IC50 of 2.5 nM in cell-free assays. CAL-101 decreases pAktS473, pAktT308, and the downstream target S6 in SU-DHL-5, KARPAS-422 and CCRF-SB cells with EC50 of 0.1 to 1.0 μM.Solubility: > 20 mg/ml in DMSO

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