ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.

Additional Information

Product Name: Also Known As: Catalog No.: Size: Molecular Weight: Species: Source: Stock: Concentration: Quality Assurance: Storage: PDF Data Sheet: NCBI RefSeq: Image(s): Shipping Method: References:

ONC201 (TIC10)

CAS# 41276-02-2

F6165-25

25 mg

386.49 Da

N/A

Synthetic

Powder

N/A

>98% by HPLC and NMR

Eligible for room temperature shipping. Store at -80°C upon receiving; avoid multiple freeze-thaw cycles after dissolving in DMSO.

Download PDF datasheet

N/A

No

Room temperature shipping

1. Allen J E, et al. (2013) Sci. Transl. Med., 5, 171ra17 2. Kline C, et al. (2016) Sci. Signal ., 9, 18r

Details

ONC201 (also called TIC10) is a potent TRAIL inducer by inhibition of ERK and AKT. ONC201 promotes nuclear localization of Foxo3a, which then enhances TRAIL transcription to induce cancer cell death. ONC201 is orally active.

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