ubpbio/K48 Ub<;sub>(2-8)</sub>/D1500/25微克

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¥1600.00
货号:D1500
浏览量:127
品牌:UBPBio
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商品描述
UbchainsareformedbyconjugatingtheC-terminalglycineresidueofUbontoanyofseveninternallysineresiduesortheaminogroupofthepreviousUb.UbchainsareclassifiedbythelysineresidueusedtolinkUbs;differentUbchaintopologiescanresultindifferentsignals.Forinstance,Ubchainslinkedthroughlysine6,11,27,29,33and48arecapableoftargetingproteinsforproteasomaldegradation;incontrast,Ubchainslinkedthroughlysine63ortheN-terminalaminogroup(linearUbchains)oftenplayimportantnonproteolyticfunctionsincludingregulationofkinaseactivationandproteintranslation.AllUbchainproductsareproducedbyusingofhumanwildtypeUbreactingwithspecificE2s.

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UbchainsareformedbyconjugatingtheC-terminalglycineresidueofUbontoanyofseveninternallysineresiduesortheaminogroupofthepreviousUb.UbchainsareclassifiedbythelysineresidueusedtolinkUbs;differentUbchaintopologiescanresultindifferentsignals.Forinstance,Ubchainslinkedthroughlysine6,11,27,29,33and48arecapableoftargetingproteinsforproteasomaldegradation;incontrast,Ubchainslinkedthroughlysine63ortheN-terminalaminogroup(linearUbchains)oftenplayimportantnonproteolyticfunctionsincludingregulationofkinaseactivationandproteintranslation.AllUbchainproductsareproducedbyusingofhumanwildtypeUbreactingwithspecificE2s.
Ubiquitin-Proteasome Biotechnologies成立于2011年,ubpbio是由科学家和投资者创立的私营企业。ubpbio致力于为学术界和工业界提供高质量的试剂和其他相关产品。ubpbio产品线包括的高度纯化的蛋白酶,E1和E2的酶,泛素和泛素衍生物,蛋白酶体抑制剂和蛋白酶基板。ubpbio不断开发创新以增加新的产品,ubpbio致力为全球的客户提供更多的帮助。在人类细胞中,有超过1000的蛋白质/酶,参与维持泛素-蛋白酶体系统的正常活动。失调的UPS已发现涉及大量的人类疾病包括癌症的病理生理,炎性疾病和神经退行性疾病。ubpbio致力为客户提供更好的泛素-蛋白酶体系统解决方案。
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ProductName:K48-Ub(2-8)
AlsoKnownAs:K48Ub(2-8)
CatalogNo.:D1500
Size:25µg
MolecularWeight:N/A
Species:Human
Source:Bacterialrecombinant
Stock:20mMTris,150mMNaCl,2mMβME,10%Glycerol
Concentration:Seetubelabel
QualityAssurance:~95%bySDS-PAGE,seedatasheetforgelimage
Storage:Storeat-80°C;avoidmultiplefreeze-thawcycles
PDFDataSheet:PDFDatasheetMSDS
NCBIRefSeq:N/A
Image(s):No
ShippingMethod:Dryiceshipping
References:1.HershkoA,etal.(1980)ProcNatlAcadSciUSA77(4),1783–1786.
2.PickartCM,(1997)FASEB11(13),1055–1066.3.HershkoA,etal.(1998)AnnRevBiochem67,425–479.
4.JiangX,etal.(2012)NatureReviewsImmunology12,35–48.