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商品描述
Necrostatin-1isapotentinhibitorofnecroptosis,aprogrammedandcaspase-independentcelldeathmechanism.Thedeathdomainreceptor-associatedserine/threoninekinaseRIP1isessentialforTNF-inducednecrosis.Necrostatin-1inhibitsRIP1andblocksTNFα-inducednecrosisofFADD-deficientJurkatcellswithanEC50valueof490nM.
AdditionalInformation
| ProductName: | Necrostatin-1 |
|---|---|
| AlsoKnownAs: | No |
| CatalogNo.: | F7101 |
| Size: | 50mg |
| MolecularWeight: | 259.33Da |
| Species: | N/A |
| Source: | Synthetic |
| Stock: | Powder |
| Concentration: | N/A |
| QualityAssurance: | >98%byHPLCandNMR |
| Storage: | EligIBLeforroomtemperatureshipping.Storeat-80°Cuponreceiving;avoidmultiplefreeze-thawcyclesafterdissolvinginDMSO. |
| PDFDataSheet: | DownloadPDFdatasheet |
| NCBIRefSeq: | N/A |
| Image(s): | (Clickimagetoenlarge) PuritycheckofNecrostatin-1byHPLC |
| ShippingMethod: | Roomtemperatureshipping |
| References: | DegterevA,etal.(2008)NatChemBiol.4(5):313-21. |
