ubpbio/环氧霉素/F1400-25/25 mg

价格
¥23000.00
货号:F1400-25
浏览量:80
品牌:UBPBio
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Epoxomicin,originallyisolatedfromActinomycessp.,isacell-permeable,potent,selectiveandirreversIBLeproteasomeinhibitor.Itinhibitschymotrypsin-like,trypsin-likeandcaspase-likeactivitiesoftheproteasome.

AdditionalInformation

Details

Epoxomicin,originallyisolatedfromActinomycessp.,isacell-permeable,potent,selectiveandirreversibleproteasomeinhibitor.Itinhibitschymotrypsin-like,trypsin-likeandcaspase-likeactivitiesoftheproteasome.

Images
(Clickimagetoenlarge)


100nMbovine26Sproteasome(Cat.#A1200)wasincubatedwithDMSOorwith10µMEpoxomicinfor10minat37°Cin20mMTris,pH7.1,50mMNaCl,2mMATP,5mMMgCl2,2mMbMEand10%glycerol.Theproteasomewasthendiluted10Xinto50µMSUC-LLVY-AMC(Cat.#G1100)inabuffercontaining20mMTris,pH7.1,2mMbME.ThereleasedAMCfluorescencewasmonitoredbyaplatereader.


EqualamountofwholecelllysatespreparedfromDMSO(lane1)or20μMEpoxomicin(lane2)-treatedHeLacellswereseparatedbySDS-PAGEandimmunoblottedwithananti-Ubantibody.HEK293TCellsweretreatedwithDMSOorEpoxomicinfor4hours.
Ubiquitin-Proteasome Biotechnologies成立于2011年,ubpbio是由科学家和投资者创立的私营企业。ubpbio致力于为学术界和工业界提供高质量的试剂和其他相关产品。ubpbio产品线包括的高度纯化的蛋白酶,E1和E2的酶,泛素和泛素衍生物,蛋白酶体抑制剂和蛋白酶基板。ubpbio不断开发创新以增加新的产品,ubpbio致力为全球的客户提供更多的帮助。在人类细胞中,有超过1000的蛋白质/酶,参与维持泛素-蛋白酶体系统的正常活动。失调的UPS已发现涉及大量的人类疾病包括癌症的病理生理,炎性疾病和神经退行性疾病。ubpbio致力为客户提供更好的泛素-蛋白酶体系统解决方案。
  • 资质认证

    获得国家资质,权威认证!

  • 全国联保

    全国联保,官方无忧售后

  • 正规发票

    正规发票,放心购买

  • 签订合同

    签订合同,保障您的权益

/**/
ProductName:Epoxomicin
AlsoKnownAs:CAS#134381-21-8
CatalogNo.:F1400-25
Size:25mg
MolecularWeight:554.72Da
Species:N/A
Source:Synthetic
Stock:Powder
Concentration:N/A
QualityAssurance:>98%byHPLCandNMR
Storage:Eligibleforroomtemperatureshipping.Storeat-80°Cuponreceiving;avoidmultiplefreeze-thawcyclesafterdissolvinginDMSO.
PDFDataSheet:DownloadPDFdatasheet
NCBIRefSeq:N/A
Image(s):No
ShippingMethod:Roomtemperatureshipping
References:1.M.Hanada,etal.(1992)J.Antibiot.,45,1746
2.L.Meng,etal.(1999)PNAS,96,10403
3.K.B.Kim,etal.Bioorg.(1999)Med.Chem.Lett.,9,3335