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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | CHOcells |
| SEQUENCE: | Humanangiopoietin-1(aa20-498)isfusedattheN-terminustoaDDDDK-tag. |
| FUSIONTAG: | DDDDKTag |
| TESTEDAPPLICATIONS: | |
| APPLICATIONS: | Thisrecombinantproteinsisforresearchuseonly. |
| BIOLOGICALACTIVITY: | InducesphosphorylationofTie-2inprimaryculturedhumanvascularendothelialcells(HUVECs).Theproteinformsmainlytetramericstructures. |
Properties
| PURITY: | >90%(SDS-PAGE) |
|---|---|
| PHYSICALSTATE: | Liquid |
| BUFFER: | 0.2um-filteredsolutioninPBScontaining0.02%CHAPS. |
| CONCENTRATION: | ~0.2mg/ml |
| STORAGECONDITIONS: | Workingaliquotsarestableforupto3monthswhenstoredat-20˚C. |
AdditionalInfo
| ALTERNATENAMES: | Ang-1,Ang1,Angpt1 |
|---|---|
| ACCESSIONNO.: | Q15389 |
| PROTEINGINO.: | 20532340 |
Background
| Angiopoietin-1(Ang-1)andangiopoietin-2(Ang-2)arecloselyrelatedsecretedligandswhichbindwithsimilaraffinitytoTie-2.Tie-2andangiopoietinshavebeenshowntoplaycriticalrolesinembryogenicangiogenesisandinmaintainingtheintegrityoftheadultvasculature.Ang-1activatesTie-2signalingonendothelialcellstopromotechemotaxis,cellsurvival,cellsprouting,vesselgrowthandstABIlization.Ang-2hasbeenidentifiedasasecretedproteinligandofTie-2andhasalternativelybeenreportedtobeanantagoNISTforAng-1inducedTie-2signalingaswellasanagonistforTie-2signaling,dependingonthecellcontext. |
