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- prosci incorporated |产品详情
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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Specifications
| SPECIES: | Human |
|---|---|
| SOURCESPECIES: | HumanCells |
| SEQUENCE: | Glu20-Val751 |
| FUSIONTAG: | C-6Histag |
| TESTEDAPPLICATIONS: | |
| APPLICATIONS: | ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly. |
Properties
| PURITY: | Greaterthan95%asdeterminedbyreducingSDS-PAGE. Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest. |
|---|---|
| PREDICTEDMOLECULARWEIGHT: | 84.4kD |
| PHYSICALSTATE: | Liquid |
| BUFFER: | Suppliedasa0.2umfilteredsolutionof20mMTrisHCl,150mMNaCl,10%Glycerol,pH7.5.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O. |
| STORAGECONDITIONS: | Storeat-20˚C,stablefor6monthsafterreceipt. Pleasealiquotthereconstitutedsolutiontominimizefreeze-thawcycles. |
AdditionalInfo
| ALTERNATENAMES: | Amiloride-sensitiveamineoxidase[copper-containing]，DAO，Diamineoxidase，Amiloride-bindingprotein1，Amineoxidasecopperdomain-containingprotein1，Histaminase，Kidneyamineoxidase，KAO，AOC1，ABP1,DAO1,ABP1,AOC1 |
|---|---|
| ACCESSIONNO.: | P19801 |
Background
| Amiloride-sensitiveamineoxidase(AOC1)belongstothecopper/topaquinoneoxidasefamily.Theproteinexistsashomodimerbydisulfideandmainlylocatedinplacentaandkidney.AOC1catalyzesthedegradationofcompoundssuchasputrescine,histamine,spermine,andspermidine,substancesinvolvedinallergicandimmuneresponses,cellproliferation,tissuedifferentiation,tumorformation,andpossIBLyapoptosis.PlacentalDAOisthoughttoplayaroleintheregulationofthefemalereproductivefunction.Theactivityofthisproteincanbeinhibitedbyamilorideinacompetitivemanner.Itisinhibitedbyamiloride,adiureticthatactsbyclosingepithelialsodiumionchannels. |
