Details:
Tested Applications	WB, ELISA
Target Information	Alpha II Spectrin, non-erythrocytic, is a 285kDa cytoskeletal protein
Product Format	Affinity Purified
Alternate Names	Alpha-II Spectrin, spectrin alpha chain non-erythrocytic 1, fodrin alpha chain
Clone	1C2B10C3C11
Host	Mouse
Isotype	IgG1
Immunogen	Peptide
Epitope	Unknown
Relevance	The spectrins are a family of widely distributed cytoskeletal proteins which are involved in actin crosslinking. Spectrin alpha-chain heterodimerizes with tissue-specific beta-chains. It is specifically expressed in nonerythrocytic cells. The protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in the gene are the cause of early infantile epileptic encephalopathy.Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. SPTAN1 has been identified as a biomarker of traumatic brain injury (TBI)
Specificity	Human SPTAN1
Reported Reactivity	Unknown
Reported Applications	Unknown

What's Happening at NeoClone Biotechnology You're probably wondering, "Now that BioLegend owns all your former catalog products, what the heck are you doing up there in Madison?" I'm glad you asked. We're still making great monoclonal antibodies, of course! NeoClone has been making custom murine antibodies via hybridoma technology for years. In fact, that's where our catalog came from in the first place! We decided that we needed to return our focus to custom projects, especially the really difficult targets that researchers had been bringing us all along. You know, the targets that other companies couldn't make due to problems with tolerance or toxicity or bizarre secondary structures. Then we decided to branch out into other methods of generating antibodies. We brought on new staff with years of experience in Antibody Phage Display and Camelid VHH antibodies. We've been upping our game in the Bioinformatics arena as well, giving us an edge in determining the best way to make YOUR antibody. Unlike other antibody development companies, we're not tied to one particular method. In the world of antibody development, one size does NOT fit all. So, you tell us what you want. We'll make sure we get it for you.