ACS Appl. Mater. InterfacesAll Publications/WebsiteOR SEARCH CITATIONS Recently ViewedYou have not visited any articles yet, Please visit some articles to see contents here. RETURN TO ISSUEPREVResearch ArticleNEXTSurface-Functionalized Model Contact Lenses with a Bioinspired Proteoglycan 4 (PRG4)-Grafted LayerMyrto KorogiannakiMyrto KorogiannakiDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, CanadaMore by Myrto Korogiannaki,Michael SamsomMichael SamsomBiomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta T2N 1N4, CanadaMore by Michael Samsom,Tannin A. SchmidtTannin A. SchmidtBiomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta T2N 1N4, CanadaMore by Tannin A. Schmidt,andHeather Sheardown*Heather SheardownDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, Canada*E-mail: [email protected]More by Heather Sheardownhttp://orcid.org/0000-0002-5404-635XCite this: ACS Appl. Mater. Interfaces 2018, 10, 36, 30125–30136Publication Date (Web):August 16, 2018Publication History Received11 June 2018Accepted16 August 2018Published online16 August 2018Published inissue 12 September 2018https://doi.org/10.1021/acsami.8b09755Copyright © 2018 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views815Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.Get e-AlertsAbstractOcular dryness and discomfort are the primary reasons for the discontinuation of contact lens wear. This is mainly due to poorly hydrated contact lens surfaces and increased friction, particularly at the end of the day and can potentially cause reduced vision or even inflammation. Proteoglycan 4 (PRG4) is a mucinous glycoprotein with boundary lubricating properties, naturally found in the eye, able to prevent tear film evaporation and protect the ocular surface during blinking. Aiming to improve the interfacial interactions between the ocular surface and the contact lens, the synthesis and characterization of surface-modified model contact lenses with PRG4 is described. Full-length recombinant human PRG4 (rhPRG4) was successfully grafted onto the surface of model conventional and silicone hydrogel (SiHy) contact lenses via its somatomedin B-like end-domain using N,N′-carbonyldiimidazole linking chemistry. Grafting was assessed by Fourier transform infrared spectroscopy-attenuated total reflectance, X-ray photoelectron spectroscopy, and radioactive (I131) labeling. Surface immobilization of rhPRG4 led to model conventional and SiHy materials with improved antifouling properties, without impacting optical transparency or causing any toxic effects to human corneal epithelial cells in vitro. The surface wettability and the boundary friction against human corneal tissue were found to be substrate-dependent, with only the rhPRG4-grafted model SiHy exhibiting a reduced contact angle and kinetic friction coefficient compared to the unmodified surfaces. Hence, clinical grade rhPRG4 can be an attractive candidate for the development of novel bioinspired SiHy contact lenses, providing improved comfort and overall lens performance.KEYWORDS:2-hydroxyethyl methacrylate (HEMA) silicone hydrogel contact lens proteoglycan 4 (PRG4)/lubricin surface modification protein deposition lubricationCited ByThis article is cited by 16 publications.Metin Karayilan, Liane Clamen, Matthew L. Becker. Polymeric Materials for Eye Surface and Intraocular Applications. Biomacromolecules 2021, 22 , 223-261. https://doi.org/10.1021/acs.biomac.0c01525Myrto Korogiannaki, Michael Samsom, Austyn Matheson, Karim Soliman, Tannin A. Schmidt, Heather Sheardown. Investigating the Synergistic Interactions of Surface Immobilized and Free Natural Ocular Lubricants for Contact Lens Applications: A Comparative Study between Hyaluronic Acid and Proteoglycan 4 (Lubricin). Langmuir 2021, 37 , 1062-1072. https://doi.org/10.1021/acs.langmuir.0c02796Carolin A. Rickert, Barbara Wittmann, Roland Fromme, Oliver Lieleg. Highly Transparent Covalent Mucin Coatings Improve the Wettability and Tribology of Hydrophobic Contact Lenses. ACS Applied Materials Interfaces 2020, 12 (25) , 28024-28033. https://doi.org/10.1021/acsami.0c06847Gongyan Liu, Kaijun Li, Haibo Wang, Li Ma, Ling Yu, Yu Nie. Stable Fabrication of Zwitterionic Coating Based on Copper-Phenolic Networks on Contact Lens with Improved Surface Wettability and Broad-Spectrum Antimicrobial Activity. ACS Applied Materials Interfaces 2020, 12 (14) , 16125-16136. https://doi.org/10.1021/acsami.0c02143Mingyu Han, Saimon M. Silva, Weiwei Lei, Anita Quigley, Robert M. I. Kapsa, Simon E. Moulton, George W. Greene. Adhesion and Self-Assembly of Lubricin (PRG4) Brush Layers on Different Substrate Surfaces. Langmuir 2019, 35 (48) , 15834-15848. https://doi.org/10.1021/acs.langmuir.9b01809Huijun Ye, Mingyu Han, Renliang Huang, Tannin A. Schmidt, Wei Qi, Zhimin He, Lisandra L. Martin, Gregory D. Jay, Rongxin Su, George W. Greene. Interactions between Lubricin and Hyaluronic Acid Synergistically Enhance Antiadhesive Properties. ACS Applied Materials Interfaces 2019, 11 (20) , 18090-18102. https://doi.org/10.1021/acsami.9b01493Khaled Seidi, Mohammad Hosein Ayoubi-Joshaghani, Mehdi Azizi, Tahereh Javaheri, Mehdi Jaymand, Effat Alizadeh, Thomas J. Webster, Amirhossein Ahmadieh Yazdi, Mostafa Niazi, Michael R. Hamblin, Zohreh Amoozgar, Rana Jahanban-Esfahlan. Bioinspired hydrogels build a bridge from bench to bedside. Nano Today 2021, 39 , 101157. https://doi.org/10.1016/j.nantod.2021.101157Nikhil G. Menon, Ruchi Goyal, Carolina Lema, Paige S. Woods, Adam P. Tanguay, Alyssa A. Morin, Nabangshu Das, Gregory D. Jay, Roman J. Krawetz, Antoine Dufour, Linda H. Shapiro, Rachel L. Redfern, Mallika Ghosh, Tannin A. Schmidt. Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation. Experimental Eye Research 2021, 208 , 108628. https://doi.org/10.1016/j.exer.2021.108628Austyn R. Matheson, Eamon J. Sheehy, Gregory D. Jay, W. Michael Scott, Fergal J. O\'Brien, Tannin A. Schmidt. The role of synovial fluid constituents in the lubrication of collagen-glycosaminoglycan scaffolds for cartilage repair. Journal of the Mechanical Behavior of Biomedical Materials 2021, 118 , 104445. https://doi.org/10.1016/j.jmbbm.2021.104445Zhiguo Li, Hongwei Cheng, Lingjie Ke, Minting Liu, Chen‐Gang Wang, Xian Jun Loh, Zibiao Li, Yun‐Long Wu. Recent Advances in New Copolymer Hydrogel‐Formed Contact Lenses for Ophthalmic Drug Delivery. ChemNanoMat 2021, 7 , 564-579. https://doi.org/10.1002/cnma.202100008Mark Willcox, Nancy Keir, Vinod Maseedupally, Simin Masoudi, Alison McDermott, Rabia Mobeen, Christine Purslow, Jacinto Santodomingo-Rubido, Silvia Tavazzi, Fabrizio Zeri, Lyndon Jones. CLEAR - Contact lens wettability, cleaning, disinfection and interactions with tears. Contact Lens and Anterior Eye 2021, 44 , 157-191. https://doi.org/10.1016/j.clae.2021.02.004Clayton S. Manasa, Saimon M. Silva, Pauline E. Desroches, Jessair Dennaoui, Mathew J. Russo, Mingyu Han, Anita F. Quigley, George W. Greene, Robert M. I. Kapsa, Simon E. Moulton. Lubricin as a tool for controlling adhesion in vivo ex vivo. Biointerphases 2021, 16 , 020802. https://doi.org/10.1116/6.0000779Shabnam Z. Bonyadi, Md. Mahmudul Hasan, Jiho Kim, Samsul Mahmood, Kyle D. Schulze, Alison C. Dunn. Review: Friction and Lubrication with High Water Content Crosslinked Hydrogels. Tribology Letters 2020, 68 https://doi.org/10.1007/s11249-020-01352-3Jian Song, Benjamin Winkeljann, Oliver Lieleg. Biopolymer‐Based Coatings: Promising Strategies to Improve the Biocompatibility and Functionality of Materials Used in Biomedical Engineering. Advanced Materials Interfaces 2020, 7 (17) , 2000850. https://doi.org/10.1002/admi.202000850Piet J Driest, Iris E Allijn, Dick J Dijkstra, Dimitrios Stamatialis, Dirk W Grijpma. Poly(ethylene glycol)‐based poly(urethane isocyanurate) hydrogels for contact lens applications. Polymer International 2020, 69 , 131-139. https://doi.org/10.1002/pi.5938Jingyi Wang, Di Chen, David A. Sullivan, Huatao Xie, Ying Li, Yang Liu. Expression of Lubricin in the Human Amniotic Membrane. Cornea 2020, 39 , 118-121. https://doi.org/10.1097/ICO.0000000000002151Export articles to MendeleyGet article recommendations from ACS based on references in your Mendeley library.Export articles to MendeleyGet article recommendations from ACS based on references in your Mendeley library. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please note: If you switch to a different device, you may be asked to login again with only your ACS ID. Please login with your ACS ID before connecting to your Mendeley account.Login with ACS ID This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy. CONTINUE

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