Guanylin is a gastrointestinal peptide hormone that activates guanyl cyclase C primarily in intestinal epithelial cells, but also in neurons. Guanylin increases intracellular levels of cGMP and induces natriuresis and diuresis in the kidney. Guanylin inhibits cell proliferation of colonic cells, inducing cell cycle arrest.
| Cas No. | 145257-03-0 |
|---|---|
| Purity | ≥95% |
| Formula | C60H90N16O22S4 |
| Formula Wt. | 1515.74 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | G8104 Info Sheet PDF |
|---|
Basu N, Saha S, Khan I, et al. Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. J Biol Chem. 2014 Jan 3;289(1):581-93. PMID: 24217248.
Fonteles MC, do Nascimento NR. Guanylin peptide family: history, interactions with ANP, and new pharmacological perspectives. Can J Physiol Pharmacol. 2011 Aug;89(8):575-85. PMID: 21815750.
Forte LR, Freeman RH, Krause WJ, et al. Guanylin peptides: cyclic GMP signaling mechanisms. Braz J Med Biol Res. 1999 Nov;32(11):1329-36. PMID: 10559833.
