Description
Polydatinisaresveratrol-relatedglucosideoriginallyfoundinPolygonumcUSPidatum.Polydatinexhibitsanticancer,anti-inflammatory,antioxidative,andanti-allergicactivities.Inlungcancercells,polydatindownregulatesexpressionofcyclinD1andBcl-2andupregulatesexpressionofBax,inducingcellcyclearrestandapoptosis.Inanimalmodelsofsepsis,polydatindecreasessepsis-inducedmortalityandlunginjurybysuppressingproductionofCOX-2,iNOS,andinflammatorycytokines.PolydatinalsodecreasesthelossofmucosalbarrierintegrityinthesmallintestineduetoOVA-inducedallergybyinhibitingmastcelldegranulation.
References
ZhangY,ZhuangZ,MengQ,etal.Polydatininhibitsgrowthoflungcancercellsbyinducingapoptosisandcausingcellcyclearrest.OncolLett.2014Jan;7(1):295-301.PMID:24348867.
YangB,LiJJ,CaoJJ,etal.Polydatinattenuatedfoodallergyviastore-operatedcalciumchannelsinmastcell.WorldJGastroenterol.2013Jul7;19(25):3980-9.PMID:23840142.
LiXH,GongX,ZhangL,etal.ProtectiveeffectsofpolydatinonsepticlunginjuryinmiceviaupregulationofHO-1.MediatorsInflamm.2013;2013:354087.PMID:23431240.
WuMJ,GongX,JiangR,etal.Polydatinprotectsagainstlipopolysaccharide-inducedfulminanthepaticfailureinD-galactosamine-sensitizedmice.IntJImmunopatholPharmacol.2012Oct-Dec;25(4):923-34.PMID:23298483.
美国LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。
美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。
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