Product ID N1744Cas No. 121032-29-9Purity ≥98%

• Description
• Product Info
• Shipping and Storage
• Downloads
• References

Description

Nelarabine is an anticancer chemotherapeutic compound used to treat T-cell malignancies such as acute lymphoblastic leukemia (ALL). Nelarabine is the prodrug of 9-β-D-arabinofuranosylguanine (ara-G), and acts as a nucleoside analog of guanosine, inhibiting DNA synthesis.

Product Info

Cas No.PurityFormulaFormula Wt.Chemical NameIUPAC NameSynonymAppearance

121032-29-9

≥98%

C11H15N5O5

297.26

(2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

(2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

506U78

White to off white powder

Shipping and Storage

Store TempShip Temp

Ambient

Ambient

Downloads

Info Sheet

N1744 Info Sheet PDF

References

Forcade E, Leguay T, Vey N, et al. Nelarabine for T cell acute lymphoblastic leukemia relapsing after allogeneic hematopoietic stem cell transplantation: an opportunity to improve survival. Biol Blood Marrow Transplant. 2013 Jul;19(7):1124-6. PMID: 23648236.

Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. PMID: 22591387.

Roecker AM, Stockert A, Kisor DF. Nelarabine in the treatment of refractory T-cell malignancies. Clin Med Insights Oncol. 2010 Dec 1;4:133-41. PMID: 21151585.

Reilly KM, Kisor DF. Profile of nelarabine: use in the treatment of T-cell acute lymphoblastic leukemia. Onco Targets Ther. 2009 Feb 18;2:219-28. PMID: 20616909.

Buie LW, Epstein SS, Lindley CM. Nelarabine: a novel purine antimetabolite antineoplastic agent. Clin Ther. 2007 Sep;29(9):1887-99. PMID: 18035189.

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