CH5424802isaninhibitorofanaplasticlymphomakinase(ALK)thatdisplaysanticancerchemotherapeuticandanti-metastaticactivitiesagainstWTandL1196MmutantALK.Thiscompoundisinclinicaltrialsasapotentialtreatmentforvariouscancers.CH5424802inducesregressionofnon-smallcelllungcancer(NSCLC)cellmetastasisinthebraininvivo,increasingsurvivalrates.Thiscompounddisplaysefficacyinsubjectsresistanttocrizotanib.
| CasNo. | 1256580-46-7 |
|---|---|
| Purity | ≥99% |
| Formula | C30H34N4O2 |
| FormulaWt. | 482.62 |
| Synonym | CH5424802,Alectinib |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C2900InfoSheetPDF |
|---|
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KodamaT,TsukaguchiT,YoshidaM,etal.SelectiveALKinhibitoralectinibwithpotentantitumoractivityinmodelsofcrizotinibresistance.CancerLett.2014Sep1;351(2):215-21.PMID:24887559.
RossiA,MaioneP,SaccoPC,etal.ALKinhibitorsandadvancednon-smallcelllungcancer(review).IntJOncol.2014Aug;45(2):499-508.PMID:24889366.
