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The monoclonal antibody to monkey CD3 (clone FN-18) was first described in 1986. The FN-18 antibody can be used in immunohistochemical staining of frozen tissues (Jonker M. et al. 2013), flow cytometric analysis (Frost P.A. et al. 2004) and intracellular staining (Aurisicchio L. et al. 2007). Further, the antibody is able to stimulate rhesus macaque PBMC (Kim J.S. et al. 2009). The FN-18 antibody has been reported to cross react with rhesus macaque, cynomolgus monkey and baboon CD3 (Nooij F.J.M. et al. 1986, Stittelaar K.J. et al. 2001 and Frost P.A. et al. 2004). Other available formats: biotin labeled (cat. no. CT162), FITC labeled (cat. no. CT163) and Cy5 labeled (cat. no. CT165).

Documentation

References list

Immunogenicity and safety of a DNA prime/adenovirus boost vaccine against rhesus CEA in nonhuman primates.
Aurisicchio, Luigi, et al. Int. J. Cancer 2007 Jun 01;120: 2290-300
White monkey syndrome in infant baboons (Papio species).
Frost, P A, et al. J. Med. Primatol. 2004 Aug;33: 197-213
Expression of CD154 by a simian immunodeficiency virus vector induces only transitory changes in rhesus macaques.
Hodara, Vida L, et al. J. Virol. 2005 Apr;79: 4679-90
Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates.
Jonker, Margreet, et al. Inflamm. Res. 2013 Feb;62: 181-94
Bortezomib can suppress activation of rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates.
Kim, Jung-Sik, et al. Transplantation 2009 Dec 27;88: 1349-59
Polymorphism for RhT3, a CD3-like cell surface antigen, expressed on rhesus monkey T lymphocytes.
Nooij, F J, et al. Immunology 1986 Dec;59: 611-20
Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques.
Stittelaar, K J, et al. Vaccine 2001 Jun 14;19: 3700-9
Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts.
Thomas, J M, et al. Transplantation 1997 Jul 15;64: 124-35

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