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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
AnthraxLethalFactorAntibodyPropertiesDescription Anti-AnthraxLethalFactor(RABBIT)Antibody-600-401-Y20 Host Rabbit TargetSpecies Bacillus KnownCrossReactivity Bacillus Clonality Polyclonal Application ELISA:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName pxo1_107 RelevantLinks UniProtKB-P15917 GeneID-3361711 NCBI-P15917 |
AnthraxLethalFactorAntibodyDescription
Background
Anthraxinfectionisinitiatedbytheinhalation,ingestion,orcutaneouscontactwithBacillusanthracisendospores.B.anthracisproducesthreepolypeptidesthatcomprisetheanthraxtoxin:protectiveantigen(PA),lethalfactor(LF),andedemafactor(EF).PAbindstotworelatedproteinsonthecellsurface;thesearetermedtumorepithelialMarker8(TEM8)/anthraxtoxinreceptor(ATR)andcapillarymorphogenesisprotein2(CMG2),althoughitisstillunclearwhichisphysiologicallyrelevant.FollowingPAbindingtoitsreceptor,PAiscleavedintotwofragmentsbyafurin-likeprotease.TheboundfragmentbindsbothLFandEF;theresultingcomplexisthenendocytosedwhichallowsthetranslocationofLFandEFintothecytoplasm.LFistheprimarytoxinofanthraxandfunctionsasahighlyspecificproteasethatcleavesmembersofthemitogen-activatedproteinkinasekinase(MAPKK)familyneartheiraminoterminus,interferingwithMAPKsignalingandinducingapoptosis.
Synonyms
AnthraxLethalFactorAntibody,Lethalfactor,Anthraxlethaltoxinendopeptidasecomponent,LF
Immunogen
Anti-Anthraxlethalfactorantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingto16aminoacidsintheinternalregionoftheAnthraxlethalfactorprotein.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-AnthraxLethalFactorAntibodyhasbeentestedforuseinELISA.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately94kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-AnthraxLethalFactorAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAnthraxLethalFactorfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.


