NGFR (p75NTR) is a low affinity neurotrophin receptor. NGFR binds neurotrophins including NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4. Nerve growth factor (NGF) is important for the development, differentation, survival of a variety of neuronal and non-neuronal cells. NGF action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75 NTR (NGFR). NGFR is a TNF-R superfamily member, reported to mediate NGF-induced apoptosis.

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