Ephreceptors,thelargestsubfamilyofreceptortyrosinekinases(RTKs),andtheirephrinligandsareimportantmediatorsofcell–cellcommunicationregulatingcellattachment,shape,andmobilityofneuronalandendothelialcellsincentralnervoussystemfunctionandindevelopment.Ephreceptorscanbedividedintotwosubgroups:EphAandEphB.Inmammals,theEphAclassconsistsofeightmembers(EphA1-7and10)thatingeneralbindtoephrin-Amemberslinkedtothecellmembranethroughaglycosylphosphatidylinositollinkage.TheEphBclassconsistsofsixmembers(EphB1-6)thatingeneralbindephrin-Bmembersthattransversethecellmembrane.TheEphrin/EPHsignalingpathwaynetworkswiththeWNTsignalingpathwayduringembryogenesis,tissueregeneration,andcarcinogenesis.RecentstudiesshowthatEph/EFNmightberelevantinnormalB-cellBIOLOGyandcouldrepresentnewpotentialprognosticMarkersandtherapeutictargetsforCLL. Abbiotec为科学界提供定制抗体生产服务，以加速从生物学到Discovery ™ 的项目  。当尚未获得针对所选抗原的抗体时，就该开发定制项目了。Abbiotec的经验丰富的员工以与开发Abbiotec目录抗体产品相同的思维方式和工具来处理定制项目：我们需要在所选应用中能特异性检测抗原的抗体。