Xboxbindingprotein1(XBP-1)isakeyproteininthemammalianunfoldedproteinresponse(UPR)thatprotectsthecellagainstthestressofmalfoldedproteinsintheendoplasmicreticulum(ER).Uponsensingunfoldedproteins,anERtransmembraneendonucleaseandkinasetermedIRE1pisactivatedandexcisesanintronfromXBP-1mRNA.ThesplicedXBP-1mRNAresultsina371aminoacidprotein(XBP-1s)whichisthentranslocatedtothenucleuswhereitbindstotheregulatoryelementsofdownstreamgenes.TogetherwithotherUPRtranscriptionfactorssuchasATF6,XBP-1stimulatestheproductionofERstressproteinsincludingtheERresidentproteinchaperonesglucoseregulatedprotein(GRP)78andGRP94. Abbiotec为科学界提供定制抗体生产服务，以加速从生物学到Discovery ™ 的项目  。当尚未获得针对所选抗原的抗体时，就该开发定制项目了。Abbiotec的经验丰富的员工以与开发Abbiotec目录抗体产品相同的思维方式和工具来处理定制项目：我们需要在所选应用中能特异性检测抗原的抗体。