LNX1Catalogue number: X2341B

Product Type	Blocking Peptide
Units	50 µg
Host	Rabbit
Species reactivity	Human
Application	Western Blotting

BackgroundLNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65

Synonyms: Numb-binding protein 1; Ligand of Numb-protein X 1

Source

Immunogen: Synthetic peptide derived from the human LNX1 protein.

Product

Product Form: Unconjugated

Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide

Concentration: See vial for concentration

ApplicationsFor use with LNX1 polyclonal antibodies (Cat. No. X2316P & X2340P).

Functional Analysis: Western Blotting

Positive Control: Protein expressed in heart, placenta, kidney, pancreas and brain.

StorageProduct should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Stability: Products are stable for one year from purchase when stored properly

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

CautionThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Nordic-MUbio​ accepts no liability for any inaccuracies or omissions in this information.

References1. Armbruester, V., et al. 'Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.; J. Virol. 78:10310-10319(2004).2. Sollerbrant, K., et al. 'The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).; J. Biol. Chem. 278:7439-7444(2003).3. Xie, Y., et al. 'Identification of a human LNX protein containing multiple PDZ domains.; Biochem. Genet. 39:117-126(2001).

Protein Reference(s)

Database Name: UniProt

Accession number: Q8TBB1

Species Accession: Human

Safety Datasheet(s) for this product:NM_Sodium Azide/wp-content/uploads/SDS/Antibody SDS with Sodium Azide Noridic-MUbio.pdf

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