AGPAT2 Antibody is a Rabbit Polyclonal antibody against AGPAT2. This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Target	AGPAT2
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human AGPAT2.
Isotype	IgG
Form	Liquid
Purification	Affinity purified.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O15120 (UniProt, ExPASy)
UniProt Secondary AC	O00516, O15106, Q5VUD3, Q5VUD4, Q9BSV7, Q9BWR7
UniProt Entry Name	PLCB_HUMAN
Gene Symbol	AGPAT2
GeneID	10555
KEGG	hsa:10555
String	9606.ENSP00000360761
Molecular Weight	Calculated MW: 27 kDa, 30 kDaObserved MW: 26 kDa
Buffer	PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration	> 1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (AGPAT2) Antibody RNA Interference Products RNA干扰（RNA interference, RNAi）是指在进化过程中高度保守的、由双链RNA（double-stranded RNA，dsRNA）诱发的、同源mRNA高效特异性降解的现象。基因沉默，主要有转录前水平的基因沉默(TGS)和转录后水平的基因沉默(PTGS)两类:TGS是指由于DNA修饰或染色体异染色质化等原因使基因不能正常转录;PTGS是启动了细胞质内靶mRNA序列特异性的降解机制。有时转基因会同时导致TGS和PTGS。 由于使用RNAi技术可以特异性剔除或关闭特定基因的表达，（长度超过三十的dsRNA会引起干扰素毒性）所以该技术已被广泛用于探索基因功能和传染性疾病及恶性肿瘤的治疗领域。