A mycobacterial antigen ESAT-6 was identified in short-term culture filtrates of Mycobacterium tuberculosis and is easily found in patients with tuberculosis. This antigen contains a variety of epitopes recognized in more than 90% of patients. ESAT-6 has recently been shown to be an ideal candidate for diagnostic test that will discriminate between infected and BCG-vaccinated persons. ESAT-6 is mainly used for antibody production and development of test systems for tuberculosis. In the future the creation of a vaccine on the basis of ESAT-6 with liposomal adjuvant or polyoxidonium is possible. This protein is from Mycobacterium tuberculosis.

Target	6 kDa Early Secretory Antigenic Target (ESAT-6)
Origin	Bacteria
Expression	Recombinant
Host	E. coli
Conjugation	Unconjugated
Form	Liquid
Purity	> 99% (15% SDS-PAGE)96.72% (RP-HPLC)
Storage	Store between 10 and -20 °C.
Molecular Weight	11.2 kDa (ESI-TOF)
Sequence	AEQQWNFAGI EAAASAIQGN VTSIHSLLDE GKQSLTKLAA AWGGSGSEAY QGVQQKWDAT ATELNNALQN LARTISEAGQ AMASTEGNVT GMFAKLAAAL EHHHHHH
Tag	C-terminal His tag.
Buffer	50 mM Tris-HCl, pH 8.0, 50 mM NaCl, 20% glycerol, 0.04% NaN3.
Concentration	0.8 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on 6 kDa Early Secretory Antigenic Target (ESAT-6) Protein RNA Interference Products RNA干扰（RNA interference, RNAi）是指在进化过程中高度保守的、由双链RNA（double-stranded RNA，dsRNA）诱发的、同源mRNA高效特异性降解的现象。基因沉默，主要有转录前水平的基因沉默(TGS)和转录后水平的基因沉默(PTGS)两类:TGS是指由于DNA修饰或染色体异染色质化等原因使基因不能正常转录;PTGS是启动了细胞质内靶mRNA序列特异性的降解机制。有时转基因会同时导致TGS和PTGS。 由于使用RNAi技术可以特异性剔除或关闭特定基因的表达，（长度超过三十的dsRNA会引起干扰素毒性）所以该技术已被广泛用于探索基因功能和传染性疾病及恶性肿瘤的治疗领域。