(+)-α-Tocopherol is a small molecule. Tocopherols are methyl-substituted hydroxychromans with a phytyl side chain. This product is semisynthetic. It is isolated from naturally occurring α-tocopherol found in vegetable oil. It is prepared using a by-product of the vegetable oil process called vegetable oil distillate (VOD) as its raw material. Soybean oil is used as a solvent in this process. α-Tocopherol is a powerful inhibitor of the proliferation of estrogen receptor positive and estrogen receptor negative human breast cancer cell lines in a dose dependent manner in vitro. Treatment at 15 µg/ml for 24 hours inhibited MDA-MB-435 cell proliferation by 71%. However, cells treated with this level of α-tocopherol exhibited reduced viability (81% vs. 96% for control cells). This product has been shown to interact with cytosolic Protein Kinase C in vascular smooth muscle cells. A review of various published research studies suggests that this product may help ward off heart attacks. α-Tocopherol is carried with LDLs and shields LDL from oxidation by free radicals. This protection leads to a decrease in LDL oxidation, which is a major cause in triggering artery stenosis. Artery blockage is due to immune cells engulfing oxidized LDL, which causes swelling and accumulation of fatty masses within the artery walls. Vitamin E may help prevent this. Isolation and analysis of tocopherols can be easily performed by a simple acetone extraction followed by HPLC.6 A C18 ODS2 column is packed with 3 µm particles and a methanol : water (99:1) mobile phase is used for isolation, resulting in detection and easy measurement of α-, δ-, and γ-tocopherol peaks. Fluorescence detection was performed with 290 nm excitation and 330 nm emission wavelengths. The equivalent of 1 mg of (+)-α-tocopherol is 1.49 International Units (IU). This oil contains approximately 400 mg of (+)-α-tocopherol per gram and is approximately 600 IU per gram.

Target	(+) alpha Tocopherol
Conjugation	Unconjugated
Storage	Store at room temperature.
Molecular Weight	430.7 Da
Molecular Formula	C29H50O2
CAS Number	59-02-9
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on (+) alpha Tocopherol RNA Interference Products RNA干扰（RNA interference, RNAi）是指在进化过程中高度保守的、由双链RNA（double-stranded RNA，dsRNA）诱发的、同源mRNA高效特异性降解的现象。基因沉默，主要有转录前水平的基因沉默(TGS)和转录后水平的基因沉默(PTGS)两类:TGS是指由于DNA修饰或染色体异染色质化等原因使基因不能正常转录;PTGS是启动了细胞质内靶mRNA序列特异性的降解机制。有时转基因会同时导致TGS和PTGS。 由于使用RNAi技术可以特异性剔除或关闭特定基因的表达，（长度超过三十的dsRNA会引起干扰素毒性）所以该技术已被广泛用于探索基因功能和传染性疾病及恶性肿瘤的治疗领域。