OVERVIEW:

Synonyms	Monoclonal PPP1R13L antibody, Anti-PPP1R13L antibody, iASPP gene antibody, NKIP1 antibody, Protein phosphatase 1 regulatory (inhibitor) subunit 13 like antibody, PPP1R13L, PPPR3L 1, RAI antibody, IASPP antibody, PPPR3L-1 antibody, PPPR3L 1 antibody, PPPR3L-1
Specificity	Human PPP1R13L
Cross Reactivity	Human. Other species not studied
Applications	Dot Blot, ICC, WB
Immunogen	PPP1R13L antibody was raised in mouse using recombinant Human Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 13 Like (Ppp1R13L)

SPECIFICATIONS:

Host	Mouse
Clone	2808C5a
Isotype	IgG1
Method of Purification	PPP1R13L antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer	PPP1R13L antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration	100 ug/ml

STORAGE & SAFETY:

Storage	Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information	This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

Usage Assay Information:

Usage Recommendations	WB: 0.2-2 ug/ml

GENERAL INFORMATION:

Biological Significance

PPP1R13L is a regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. It also blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis{EC1,EC2,EC3,EC4}.

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