OVERVIEW:

Synonyms	MonoclonalAxin1antibody,Anti-Axin1antibody,AXINantibody,Axin-1,Axisinhibitionprotein1antibody,Axin1,Axin1,hAxinantibody,Axin-1antibody,Axin1antibody,Axin-1antibody,axin1antibody,MGC52315antibody
Specificity	Human
CrossReactivity	Tobedeterminedbyend-user.
Applications	ELISA,IF,WB
Immunogen	Axin1antibodywasraisedinmouseusingrecombinanthumanAxin1(546-752aa)purifiedfromE.coliastheimmunogen.

SPECIFICATIONS:

Host	Mouse
Clone	AT1A4
Isotype	IgG2bkappa
Source	Anti-humanAxin1antibody,cloneAT1A4,isderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanAxin1protein.
MethodofPurification	Axin1antibodywaspurifiedbyprotein-Gaffinitychromatography
Form&Buffer	SuppliedasaliquidinPBS,pH7.4,with0.1%NaN3.
Concentration	1mg/ml

STORAGE&SAFETY:

Storage	Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles.

UsageAssayInformation:

UsageRecommendations	IF:1:250-:500,WB:1:250-1:500

GENERALINFORMATION:

BIOLOGicalSignificance

Axinwasoriginallyidentifiedastheproductofthemousegenecalled?fused?orfu(renamedAxin),andhassincebeenshowntoplayacrucialroleincontrollingaxisformationduringembryonicdevelopment.Axin1ischaracterizedtobeatumorsuppressorandnumerousgenemutationshavebeenidentifiedthroughoutAxin1fromanumberofdifferentcancers.Axincanidentifyinamousemutantstrain,createdbyrandomintegrationofatransgene.Also,Axin1playsanimportantroleintheformationoftheembryonicneuralaxis.Recently,itwasreportedthatAxinisfoundinmitoticspindlesandcentrosomes.

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