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蚂蚁淘在线 / 品牌中心 / Zenbio / Zenbio/人外体/EXPLMSC-F100/100µ；G

Zenbio/人外体/EXPLMSC-F100/100µ；G

价格
￥17360.00
货号：EXPLMSC-F100
浏览量：127
品牌：Zenbio
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商品描述
HumanPlacentalDerivedMesenchymalStemCellExosomes,Frozen

Zenbiohumanpre-ADIpocytes(adiposederivedadultstemcells)andplacentalmesenchymalstemcells(MSC)arecharacterizedbytheirself-renewingcapacityandABIlitytodifferentiateintochondrocytes,adipocytes,andosteocytes.Thismakesthemattractivestartingmaterialsfortissueengineeringandregenerativemedicineapplications.

Sincefewtransplantedcellspersistinvivo,thebeneficialeffectsofcelltherapymaylieinthesecretedfactorsbeingtheactivecomponentofthistreatment.AkeypartofparacrinesecretionisExosomes,whicharemembranevesiclesthatarestoredintracellularlyinendosomalcompartmentsandaresecretedwhenthesestructuresfusewiththecellplasmamembrane.

  • Exosomescontainprotein,DNA,andRNA,thusmakingthemanattractivevectorofparacrinesignalsdeliveredbystemcells.
  • Exosomesmayalsobe"loaded"withpredeterminedproteinsandnucleicacidtoachieveadesiredeffect(1).
  • Exosomescanbestoredasan"off-the-shelf"producthavingthepotentialforcircumventingmanyofthelimitationsofviablecellsfortherapeuticapplicationsinregenerativemedicine.
  • Invitro,exosomesfrompre-adipocytesstimulatecellproliferationinawoundhealingmodel.
  • Invivo,adipose-graftderivedexosomeshavebeenshowntobeapromisingtoolforskinrepairandremodeling(2)

QualityControl:AllcellshavebeenscreenednegativeforHIV-1,HIV-2,Hep-B,Hep-CandSyphilis.AllisolatedandconcentratedexosomesundergoincludesParticlemeandiameter,Proteinconcentration,RNAconcentrationandConcentrationofparticles/ml.

Exosome-mediatedfibroblastproliferation

Afterthecellmonolayerwas"wounded"usingacellscraper,thecultureswerewashedandfedwithDMEM+10%exosome-freeFBS(Control),orDMEM+10%exosome-freeFBSsupplementedwith25µgofpre-adipocyteexosomes(ExosomeTreated).Aftera5dayincubation,fibroblastproliferationclosedthegapbetweenthetwoedgesofthewoundedmonolayeronlyinthemediumsupplementedwithexosomes.Thesedatasupportthenotionthatfactorsincludingexosomessecretedbypre-adipocytes(adiposetissue-derivedMSC)playaroleinwoundhealingandtissueregeneration,byfacilitatingcellularproliferation

Human Exosomes Control and Treated Photograph
ZenBio提供了多种检测方法来检测作为潜在糖尿病或肥胖疗法的化合物。客户可以从以下任何一种检测方法中进行选择，或者我们可以设计一个针对每个客户的特定研究需求的定制程序。