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公司地址
苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Overview:
| ProductName | 17-DMAG |
| Description | Hsp90inhibitor |
| Purity | >98%(TLC);NMR(Conforms) |
| CASNo. | 467214-20-6 |
| MolecularFormula | C32H48N4O8 |
| MolecularWeight | 616.8 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Inhibitor |
| Solubility | SolubleinDMSO(30mg/ml)andethanol(10mg/ml) |
| Source | Synthetic |
| Appearance | PurpleSolid |
| SMILES | C[[email protected]]1C[[email protected]@H]([[email protected]@H]([[email protected]](/C=C(/[[email protected]@H]([[email protected]](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)C)C)O)OC |
| InChI | InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,( |
| InChIKey | KUFRQPKVAWMTJO-LMZWQJSESA-N |
| SafetyPhrases | Classification:Caution:Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS24/25-AvoidcontactwithskinandeyesS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotection |
| CiteThisProduct | 17-DMAG(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-114) |
BIOLOGicalDescription
| AlternativeNames | Alvespimycin,17DMAG,17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin,17-(dimethylaminoethylamino)-17-demethoxygeldanamycin,17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin,17-dimethylaminoethylamino-17-demethoxy-geldanamycin,17-DMAG,17-Dimethylaminoethylamino,17-Demethoxygeldanamycin,[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-21-[2-(dimethylamino)ethylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azABIcyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]carbamate |
| ResearchAreas | Cancer,HeatShock |
| PubChemID | 5288674 |
| ScientificBackground | 17-DMAGisawatersoluble&cell-permeableanalogofGeldanamycinand17-AAG(1).ItbindstotheAPTasesiteofhumanHsp90awithhighaffinity,hascytotoxicactivityagainstmanycancercelllines(2),andactsasangiogenesisinhibitor(3).ThisHsp90inhibitorshowspromiseinpreclinicalmodels.17-DMAGhasexcellentbioavailability,iswidelydistributedtotissues,andisquantitativelymetabolizedmuchlessthanis17-AAG. |
| References | 1.BullE.E.,etal.(2004)Clin.CancerRes.10:8077. 2.GossettD.R.etal.(2005)Gynecol.Oncol.96:381. 3.KaurG.etal.(2004)Clin.CancerRes.10:4813. |
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