Cat-Nr.	101-MBi34
Size	50 µg
Price	230 €
Category	Monoclonal Antibody
Label	Biotin
Clone Nr.	(#4(20I6))
Isotype	IgG1
Species Reactivity	Human
Formulation	lyophilized
Buffer	PBS
Stabilizer/Carrier	BSA (50x), 0.02% sodium azide
Reconstitution	Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Stability and Storage	The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Preparation	The monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular KDR (110 kDa) as the immunizing antigen. Mouse IgG1 antibody (clone 4 (20I6)) from hybridomas was purified from cell culture supernatant by Protein G chromatography and then biotinylated using a standard protocol. The monoclonal antibody will detect native human VEGFR-2/KDR in ELISA experiments and on the surface of different human cell types.
Antigen	recombinant human soluble extracellular KDR (D7)
Application	WB, FC, E, IHC
Synonyms	vascular endothelial growth factor receptor-2 ; KDR; FLK1; CD309; VEGF receptor 2; VEGFR2; kinase insert domain protein receptor
Description	VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.
Uniprot ID	P35968
Protein RefSeq	NP_002244.1
mRNA RefSeq	NM_002253.2

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