Cat-Nr.	100-050S
Size	2 µg
Price	75 €
Source	E. coli
Formulation	lyophilized
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Length [aa]	179
Molecular Weight	19.1 kDa
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Biological Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Species Reactivity	Monkey, Mouse, Human, Bacteria, Virus
Synonyms	IL11; AGIF; IL-11
Description	IL-11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.
Protein Sequence	MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Uniprot ID	P20809
Protein RefSeq	NP_000632.1
mRNA RefSeq	NM_000641

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