Cat-Nr.	101-M43A
Size	100 µg
Price	275 €
Category	Monoclonal Antibody
Clone Nr.	(#5C34)
Isotype	IgG1
Species Reactivity	Human
Formulation	lyophilized
Buffer	PBS
Reconstitution	Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and Storage	Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.
Preparation	This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human platelet-derived growth factor receptor alpha extracellular domain.
Antigen	recombinant human PDGFR beta extracellular domain
Application	WB
Synonyms	PDGFRB; JTK12; PDGFR; CD140B; PDGFR1; PDGFR-1
Description	PDGF is a major serum mitogen that can exist as a homo or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF Rα binds all three PDGF isoforms with high affinity, PDGF Rβ binds PDGF-BB only with highaffinity. Both PDGF Rα and PDGF Rβ are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization and signal transduction. The expression of the α and β receptors is independently regulated in various cell types. Recombinant soluble PDGF Rβ binds PDGF with high affinity and is potent PDGF antagonist.
Uniprot ID	P09619
Protein RefSeq	NP_002600
mRNA RefSeq	NM_002609.3

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