Cat-Nr.	S01-036S
Size	10 µg
Price	75 €
Source	E. coli
Formulation	lyophilized
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Length [aa]	133
Molecular Weight	14.9 kDa
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Biological Activity	sTRAIL Receptor 2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of sTRAIL Receptor 2, TRAIL-induced TNF is suppressed.
Species Reactivity	Human
Synonyms	TNFRSF10B; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
Description	TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic death domain, which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Protein Sequence	MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES
Uniprot ID	O14763
Protein RefSeq	NP_003833.4
mRNA RefSeq	NM_003842.4

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