productdatasheet

CatalogNo.:2125

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Cellularresponsesinducedbythepro-inflammatorycytokineIL-1requireIL-1receptorcomplex(IL-1R1andIL-1RacP).Recently,MyD88wasidentifiedasanadaptermoleculeintheIL-1signalingpathway.MyD88associateswithandrecruitsIRAKtotheIL-1receptor.DominantnegativemutantsofMyD88attenuateIL-1R-mediatedNF-κBactivation.MyD88alsofunctionsasaregulatormoleculeforIL-18receptorandhumanTollreceptor,membersoftheToll/IL-1Rfamilyofreceptors.TargeteddisruptionoftheMyD88generesultsinlossofcellularresponsestoIL-1andIL-18,andMyD88-deficientmicelackresponsestoLPSwhichrequireToll-likereceptors2and4(TLR2andTLR4)asthesignalingreceptors.MyD88isageneraladapterproteinfortheToll/IL-1RfamilyofreceptorsandplaysanimportantroleintheinflammatoryresponsesinducedbycytokinesIL-1,IL-18,andLPS.MyD88isexpressedinavarietyoftissues.

Antigen:Peptidecorrespondingtoaa233-248ofhumanMyD88.ThesequencediffersfrommouseMyD88bytwoaminoacids.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

ThisantibodyrecognizeshumanandmouseMyD88(35kD).

Immunoblotting:useat1:500-1:1,000dilution.

Positivecontrol:WholecelllysatefromJurkatcells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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