- TCP Ports list (3498 ports in list)_zyb378747350的专栏
- ...L, N and Ttype Ca<sup>2+</sup> channel blocker (ab143236)
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- AntiHuman Caspase10 (CT)
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- 最新代理美国QED Bioscience公司全线产品
Anti-MLLN-TerminusMonoclonalAntibody
MLL(MixedLineageLeukemia)isaproto-oncogenethatismutatedinavarietyofacuteleukemias.MLLisproteolyticallyprocessedinto2fragments,MLLNandMLLC,thatdisplayoppositetranscriptionalproperties.ProcessedMLLNandMLLC
associatewitheachotherviaN-terminalandC-terminalintramolecularinteractiondomains.MLLprocessingoccursrapidlyaftertranslationandisfollowedby
phosphorylationofMLLC.MLLNdisplays
transcriptionalrepressionactivity,whereasMLLChasstrongtranscriptionalactivationproperties.Leukemia-associatedMLLfusionproteinslacktheMLLprocessingsites,donotundergocleavage,andareunabletointeractwithMLLC.These
observationssuggestthatposttranslationalmodificationsofMLLmaybeinvolvedinregulatingMLLactivityasatranscriptionfactor,andthisaspectofitsfunctionisperturbedbyleukemogenicfusions.
ThisantibodyrecognizeshumanandmouseMLLN.
APPLICATIONSImmunoblotting:useat2ug/ml.Abandof
~300kDaisdetected.
K562cellnuclearextractwith#34041at2ug/ml.
Immunoprecipitation:use2-10ugper500ul(1-3mg/ml)ofcelllysate.
Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
Positivecontrol:K562celllysate.
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
YokoyamaAetal.2002Blood100:3710-
3718.
YokoyamaAetal.2005Cell123:207-218.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.
QED生物科技为科研客户提供优质的单克隆和多克隆抗体产品。 是一家提供全面服务的并提供额外服务的公司。能提供超过1500的单克隆和多克隆抗体的用于多领域的研究。
