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- ...L, N and Ttype Ca<sup>2+</sup> channel blocker (ab143236)
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Anti-Bcl-3MonoclonalAntibody
CatalogNo.:11067(clone150-3.5)Size:100ugIgGinPBS,pH7.4,purifiedbyProteinGaffinitychromatography.
ThegeneencodingBcl-3wasfirstidentifiedasthegenealteredinsomecasesofchronicBcelllymphocyticleukemiaandwaslaterfoundtobelongtotheIκBsubfamilyofinhibitorsofNFκBtranscriptionfactors.Bcl-3doesnothaveDNA-bindingactivity,butitinteractswithNFκB1andNFκB2which,whenboundtoDNA,repressgenetranscription.Therefore,Bcl-3maypromotegeneexpressionthatisrepressedbymembersoftheNFκBfamily.Bcl-3RNAishighlyexpressedinspleenandliverwithlowerlevelsofexpressioninheart,skeletalmuscle,lung,kidney,andtestes.
Immunogen:RecombinantmouseBcl-3-6His.
HostSpecies:HamsterSubtype:IgG1StABIlizers:None
Preservatives:None.Availableonrequest.
SPECIFICITYThisantibodyrecognizeshumanandmouseBcl-3.
Immunoblotting:useat2ug/ml.Abandofapprox.64kDaisdetected.
ELISA:Endusershoulddetermineoptimalconcentrationforeachsample.
Positivecontrol:JurkatTcelllysate.
SeeBassettiMFJetal.2009InternationalImmunology21:339-348.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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