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Type:Protein
SpeciesReactivity:M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFGF-8isamemberofthefibroblastgrowthfactorfamilythatwasoriginallydiscoveredasanandrogen-inducedgrowthfactoressentialfortheandrogen-dependentgrowthofmousemammarycarcinomacells.ThemouseFGF-8primarytranscriptisalternativelysplicedtogenerateatleast7secretedisoformsthatdifferonlyattheiraminoterminis.TheFGF-8isoformsdifferentiallyactivatethevariousalternativelysplicedformsoffibroblastgrowthfactorreceptors1-3,andfibroblastgrowthfactorreceptor4.FGF-8bhasbeenshowntoactivatethe‘c’spliceformofFGFR2,FGFR3,andFGFR4.Duringmousedevelopment,expressionofFGF-8wasrestrictedtoembryonicdays9through13.ThepatternofFGF-8expressionduringmousedevelopmentsuggestsaroleforFGF-8inmultipleregionsofectodermaldifferentiationinthepost-gastrulationmouseembryo.Theseincludearoleinoutgrowthandpatterningoftheface,limbs,andcentralnervoussystemofthevertebrate.TheFGF-8locushasbeenmappedtomousechromosome19andhumanchromosome10(MacArthur,C.A.etal.,1995,Development,121:3603-3613;Crossley,P.H.etal.,1996,Cell,84:127-136).
