NeuregulinisasignalingproteinforErbB2/ErbB4receptorheterodimersonthecardiacmusclecells,playinganimportantroleinheartstructureandfunctionthroughinducingErbB2/ErbB4receptorphosphorylationandcardiomyocytedifferentiation.Researchonmolecularleveldiscoveredthatneuregulinrecombinantcouldmakedisturbedmyocardialcellstructureintoorderandstrengthentheconnectionbetweenmyocardialcellsbyintercalateddiscsre-organization.Pharmacodynamicexperimentsinanimalsshowedthatneuregulin(NRG1)recombinantcanreducethedegreeofdamageonmyocardialcellscausedbyischemia,hypoxiaandviralinfection..

References:

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Image: Heregulin-B2structureandsequence