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蚂蚁淘在线 / 品牌中心 / Neuromics / Neuromics/Lipin 1 (LPIN1)/RA25079/100 ul

Neuromics/Lipin 1 (LPIN1)/RA25079/100 ul

价格
￥6300.00
货号：RA25079-100ul
浏览量：127
品牌：Neuromics
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商品描述

Type:RabbitIgG

 

Applications:IHC;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:H;M;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AffinityPurified-liquid

 

Immunogen:Asyntheticpeptidetoaninternalregion(withinresidues300-400)ofthehumanLPIN1protein.[Swiss-Prot#Q14693].

 

Picture

TheLipinfamilyofnuclearproteinscontainsthreemembers:Lipin-1,Lipin-2andLipin-3,allofwhichcontainanuclearsignalsequence,ahighlyconservedamino-terminal(NLIP)domainandacarboxy-terminal(CLIP)domain.LPIN1(Lipin-1)iscrucialfornormalADIposetissuedevelopmentandmetabolism.LPIN1selectivelyactivatesasubsetofPGC-1átargetpathways,includingfattyacidoxidationandmitochondrialoxidativephosphorylationbyinducingexpressionofthenuclearreceptorPPARá.LPIN1alsoinactivatesthelipogenicprogramandsuppressescirculatinglipidlevels.AnabundanceofLPIN1promotesfataccumulationandinsulinsensitivity,whereasadeficiencyinLPIN1maydeternormaladiposetissuedevelopment,resultingininsulinresistanceandlipodystrophy,aheterogeneousgroupofdisorderscharacterizedbylossofbodyfat,fattyliver,hypertriglyceridemiaandinsulinresistance.

Image:LPIN1stainingofmousepancreastissue.

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