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Lumican(LUM)isthemajorkeratansulfateproteoglycanofthecorneaanditbindscollagenfibrils.Innoncornealtissues,lumicanispresentasalowornonsulfatedglycoproteinandhasbeenfoundintheaorta,cartilage,liver,skeletalmuscle,kidney,pancreas,brain,placentaandlung.Complicationsofthecorneahavebeenconfirmedusinglumican-nullmice.Thesemiceexhibitcornealopacity,skinfragility,andimpairedcollagenfibrillogenesis.Morerecentstudiesshowlumicanhasanintegralroleincellmigration,adhesionandproliferation.Theexpressionoflumicanhasalsobeenexaminedinbreast,pancreaticandcolorectalcancer.Theaffectoflumicandependsonthetypeofcancerasithasbeenshowntohavebothapositiveandnegativeaffectontumorgrowth.
RelatedTerms/Symbols
- LUM
- LDC
- SLRR2D
- P51884
- Lumicanproteoglycan
- majorkeratansulfateproteoglycan
Clone:Lum-1
Host:Mouse
Isotype:IgM
Purity:Affinitypurifiedonthiophiliccolumn
Form:Liquid,1mL/vial
Concentration:0.1mg/mL
Storage: -20°C.
Specificity:ThisLumicanantibodyrecognisesaproteinepitopeinlumicanderivedfromhuman,bovine,porcine&mousetissues.
How_To_Use:
Applications
- WesternBlot:recommendeddilution0.2mg/mL
- IHC
TechnicalNotes
ThisepitopeisbestrecognizedafterkeratanaseandkeratanaseIItreatment/digestion
ofsection(IHC)ortissueextracts(forWesternanalyses).InsomeIHCtissueanalyses,
chondroitinasetreatmentmayalsobeused,asthissecondenzymetreatmentfacilitates
antibodypenetrationintothetissue.
MD Bioproducts的ELISA法目录编号名称数量/尺寸M036005N小鼠OVA-IgE ELISA96口井M046006酶联免疫吸附测定96口井M046008Aggrecanase活性ELISA96口井M046009Aggrecanase活性,灵敏的ELISA96口井M046010降钙素ELISA96口井M056011内啡肽(β-Endorphin)ELISA96口井M046013EPO ELISA96口井M046043HtrA丝氨酸肽酶-1(HtrA1)ELISA,人类96口井M056014亮氨酸-脑啡肽酶联免疫吸附测定96口井M046015MMP-13(活化)ELISA96口井M046016PTH,完整ELISA96口井M056018P物质ELISA96口井

