Specifications

BackgroundTanespimycin (17-AAG) is a semi-synthetic analog of geldanamycin which is less toxic and more stable¹. Selectively binds to and inhibits HSP90 from tumor cells displaying a 100-fold higher affinity for tumor cell-derived over normal cell HSP90². Displays anti-angiogenic activity³. Sensitizes tumor cells to apoptosis in response to such agents as taxol⁴ and cisplatin⁵. Cell permeable.

Product InformationPurity:                             >98% by TLCMW:                                585.7Formula:                        C31H43N3O8Physical State:               Lyophilized red to dark red powderAmount:                         1mg or 5mgSolubility:                      >50 mg/ml in DMSO; 5 mg/mL in ethanolStorage:                          Store desiccated at -20°C. Store solutions at -20°C for 3 months.

References

1. TW Schulte et al. Cancer Chemother. Pharmacol. 1998 42:2732. A Kamal et al. Nature 2003 425:4073. G Kaur et al. Clin. Cancer Res. 2004 10:48134. DB Solit et al. Cancer Res. 2003 63:21395. IA Vasilevskaya et al. Mol. Pharmacol. 2004 65:235

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