Specifications

Thalidomide binds to the E3 ubiquitin ligase complex formed between cereblon (CRBN), damaged DNA binding protein 1 (DDB1), and Cul4A inhibiting ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Thalidomide initiates its teratogenic effects by binding to CRBN and inhibiting the associated ubiquitin E3 ligase activity. Cell permeable.

Caution: Teratogenic

Info

Purity	>98% (TLC); NMR (Conforms)
Quantity	100 mg, 200 mg
Molecular Weight	258.2 Da
Physical State	White powder
Solubility	DMSO (5 mg/ml)
CAS No.
Storage	4°C, (-20°C Long term). Store solutions at -20°C for up to three months. The product can be shipped at room temperature.

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