Specifications

MLN9708 is a proteasome inhibitor. Much like Bortezomib, the active form of MLN9708 selectively and reversibly inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome, with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. MLN9708 is the prodrug form of MLN2238; the two compounds are also known as ixazomib citrate and ixazomib, respectively. Under physiological conditions, the boronic citrate ester is rapidly hydrolyzed to a boronic acid. Ixazomib has been used in combination therapy as a treament for multiple myeloma, and studies indicate that it has the potential to treat other cancers as well.

Info

Chemical Formula	C20H23BCl2N2O9
CAS No.	1201902-80-8
Purity	>99.6 by HPLC
Molecular Weight	517.12 Da
Physical State	Lyophilized powder
Quantity	5 mg
Solubility	DMSO (103 mg/mL)
Storage	Store dessicated as supplied at -20°C for 2 years.

Product can be shipped at room temperature.

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