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Specifications
Cbl-bisanE3ligasewhichregulatesalargenumberofdifferentsignalingmoleculesinthecell.ThemammalianCblfamilyofproteinsishighlyconservedhroughoutevolutionfromnematodestohumansandconsistsofc-Cbl,Cbl-b,andCbl-3.AllthreemembersoftheCblfamilyofproteinsshareahighlyHomologoustyrosinekinase-binding(TKB)domain.TheTKBdomainisfollowedbyahighlyconservedhelicallinker(L)domainandaRING(reallyinterestingnewgene)finger(RF)domain,whichbindtoubiquitin-conjugatingenzymes(E2).Incontrast,theC-terminalregionsofthisfamilyofproteinsarelessconserved.Cbl-bhasbeendemonstratedtoplayacrucialroleinestablishingthethresholdforT-cellactivationandcontrollingperipheralT-celltoleranceviamultiplemechanisms.
Info
| Purity | > 95%bySDS-PAGE |
| MolecularWeight | 48kDa |
| Quantity | 25 mg |
| PhysicalState | Liquid |
| Source | HumanRecombinant |
| Tag | His6+HA |
| Storage | Storeat-80°C,avoidingrepeatedfreeze-thawcycles. |


