Specifications

Background

Binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Impairs prostate cancer cell growth and proliferation2. Suppresses growth of pancreatic cancer cells via down-regulation of Notch1 signaling3. Cell permeable. Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.

Product Information

Purity:                               >98% by TLCMW:                                   354.4Formula:                           C21H22O5CAS No.                             6754-58-1Physical State:                  Lyophilized yellow powderAmount:                            5mg, 25mgSolubility:                          35 mg/mL in DMSO or ethanolStorage:                             Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 1 month.

References

1. Y Sasazawa et al. ACS Chem. Biol. 2012 7:8922. R Vene et al. Mol. Med. 2012 18:12923. S Kunnimalaiyaan et al. Mol. Cancer Ther. 2015 14:1395

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