Specifications

Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Product Information

Purity:                                >95%MW:                                    656.23Formula:                            C30H45N5O7S.HClCAS Number                      2097971-11-2Physical State:                   Lyophilized white solidQuantity:                           5mg; 10mg; 25mgSolubility:                          65 mg/mL in DMSO; 65 mg/mL in waterStorage:                             Store at -20C.

References

1. Zengerle et al (2015) Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 10 1770 PMID: 260356252. Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID: 28302825

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