Specifications

Amount	0.8 nmol
State	Liquid
Molecular Weight	21,077 Da
Source	Human Recombinant
Fusion Tag	None
Accession Number	Q969M7
Alternate Names	Nedd8 carrier protein, Nedd8 conjugating enzyme 2 (NCE2)
Storage	-80°C, avoid freeze/thaw cycles
Stability	1 year under recommended storage conditions
Recommended Use	Enzyme concentration of 100 nM – 1 mM is recommended for in vitro conjugation.

Description

UBE2F is an E2 conjugation enzyme that is involved in the ubiquitylation of target substrates, along with E1 and E3 enzymes. UBE2F mediates the transfer of NEDD8 from NEDD8-activating enzyme E1 (UBA3-NAE1 complex) to a substrate protein. This E2 enzyme has been shown to associate with the both NEDD8 E3 ligase and RBX2, yet displays different target cullin specificities than a similar UBE2M/RBX1 E2/E3 complex.

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