Specifications

Background

Chloroquine diphosphate is a 4-aminoquinoline anti-malarial and anti-rheumatoid agent, also acting as an ATM activator. Inhibits autophagy in a variety of cell lines¹. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer². Eliminates cancer stem cells via deregulation of Jak2 and DNMT1³. Displays synergy when combined with the Raf inhibitor, vemurafenib, in brain tumors⁴. Cell permeable and active in vivo.

Product Information

Purity:                            >98.0% by TLCMW:                                515.9Formula:                        C18H26ClN3.2H3O4PCAS No.                          50-63-5Physical State:               Lyophilized white powderAmount:                         5mg, 25mg, 50mgSolubility:                      25 mg/mL in waterStorage:                         Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. HB Frieboes et al. JOP 2014 15:1892. PD Jiang et al. Biomed. Pharmacother. 2010 64:6093. DS Choi et al. Stem Cells 2014 32:23094. JM Mulcahy Levy et al. Cancer Discov. 2014 4:773

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