Specifications

Ubiquitin (Ub), a highly conserved, 8 kDa polypeptide present in all eukaryotic cells, is conjugated to the ε-amino group of lysine residues in the target protein through the sequential action of three enzymes, an E1 Ub activating enzyme, an E2 conjugating enzyme, and an E3 ligase. In addition, the seven lysines within Ub itself can serve as Ub acceptors leading to the formation of polyubiquitin chains. Among these K48 and K63 linkages are well characterized. K48-linked polyubiquitylation targets proteins for proteasomal degradation whereas K63 linkages regulate signaling events, receptor endocytosis and immune responses. Polyubiquitin linkages at other lysines are less prominent and their physiological role remains largely unknown.

Info

Species	Rabbit
Purity	>90%
Isotype	IgG1
Supplied as	125 ug at 1.25 mg/mL
Storage	Stable for weeks at +4°C. Sodium azide can be added to an antibody preparation to a final concentration 0.02% (w/v). For long term storage (6 to 12 months) store at -20°C. Avoid multiple freeze/thaw cycles.

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